DES MOINES, Iowa (AP) — No one has matched the jackpot-winning numbers in Wednesday night’s Powerball drawing, and the prize has increased to an estimated $478 million.

The next drawing will be Saturday. Nearly three months have passed without a winner of the big prize.

The chance of winning the Powerball is incredibly small, at 292.2 million-to-1. But players have much better odds, of about 1 in 25, of winning smaller prizes ranging from $4 to $1 million.

COLUMBUS, Ohio (AP) — A drug used to sedate elephants and other large animals that is 100 times as potent as the fentanyl (FEHN’-tuh-nihl) already escalating the country’s heroin troubles is suspected in spates of overdoses in several states.

Authorities say they’ve found carfentanil (kahr-FEHN’-tuh-nihl) mixed with or passed off as much weaker heroin.

A central Ohio man suspected of selling carfentanil as heroin was indicted this week on charges including murder in connection with 10 overdoses, including one death. Investigators are still trying to track down the source.

Carfentanil also has been suspected in overdoses or found in Akron and Cincinnati, central Kentucky and western Florida.

A coroner in Cincinnati warned that the overdose antidote naloxone might not be enough to save people overdosing on carfentanil.

BRIDGEPORT, Neb. (AP) — A federal safety agency wants to penalize a Nebraska Panhandle grain facility for what the agency says are several violations.

The Occupational Safety and Health Administration is proposing nearly $62,000 in penalties for the New Alliance facility in Bridgeport. The agency says that during February and March inspections, officials found violations that included the lack of guardrails to prevent falls of up to 15 feet. The agency also says workers at the facility were exposed to grain dust explosions because the facility didn’t prevent grain dust accumulation.

New Alliance is a division of Western Cooperative Co., commonly known as Westco. Westco general manager David Briggs would say only that Westco is cooperating with OSHA.